Synthesis and anticancer evaluation of some coumarin and azacoumarin derivatives

Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones lactams, respectively, which indispensable heterocyclic units to both chemists biochemists. 1-Aza derivatives, ultimately metabolize as the corresponding 8-hydroxy coumarins in biological system therefore found be very good anti-inflammatory, anti-cancer, analgesic agents. A series hybrid substituted azacoumarin-3-carboxylic acid derivatives (8-methoxycoumarin-3-carboxylic (4a), 8-methoxyazacoumarin-3-carboxylic (4b), 5-bromo-8-methoxycoumarin-3-carboxylic (5a), 5-bromo-8-methoxyazacoumarin-3-carboxylic (5b), 2-acetoxy-5-bromo-8-methoxyquinoline-3-carboxylic (6), 5,7-di(phenylazo)-8-methoxycoumarin-3-carboxylic (7) were synthesized structurally proved using spectral elemental analysis data. Substituted coumarin-3-carboxylic (4a 5a) (4b, 5b 6) tested for their vitro cytotoxic activity against MCF-7 HepG-2 cell lines.